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This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics. This book provides abundant applications of computers in formulation designing and characterization are provided as examples, case studies and illustrations. Short reviews of software, databases and expert systems have also been added to culminate the interest of readers for novel applications in formulation development and drug delivery. Computer-aided pharmaceutics and drug delivery is an authoritative reference source for all the latest scholarly update on emerging developments in computed assisted techniques for drug designing and development. The book is ideally designed for pharmacists, medical practitioners, students and researchers.
History and Present Scenario of Computers in Pharmaceutical Research and Development
Historical Developments on Computer Applications in Pharmaceutics
Computer-Aided Formulation Development
Quality by Design in Pharmaceutical Development
Teaching Principles of DoE as an Element of QbD for Pharmacy Students
Computer-Assisted Manufacturing of Medicines
Computer-Aided Biopharmaceutical Characterization: Gastrointestinal Absorption Simulation and In Silico Computational Modeling
Computer Simulation and Modeling in Pharmacokinetics and Pharmacodynamics
Physiologically Based Pharmacokinetic (PBPK) Modelling
Computers in Clinical Development
Artificial Intelligence and Its Applications in Drug Discovery, Formulation Development, and Healthcare
Robotic Automation of Pharmaceutical and Life Science Industries
Soft Robots for the Delivery of Drugs
Online Literature Searching for Research Projects in Pharmaceutical Sciences
Patent Searching
Computer Aided Drug Design
Quantitative Structure-Property Relationship (QSPR) Modeling Applications in Formulation Development
Modelling Approaches for Studies of Drug-Polymer Interactions in Drug Delivery Systems
Computers in Pharmaceutical Analysis
elemedicine
Bioinformatics in Drug Design and Delivery
Statistical Modeling Techniques
Molecular Modeling of Nanoparticles
Pharmaceutics Informatics: Bio/Chemoinformatics in Drug Delivery
Computer-Aided Development and Testing of Human Extra-Thoracic Airway Models for Inhalation Drug Delivery